Botulax 100U is a purified botulinum toxin type A manufactured in South Korea by Hugel, Inc. — one of the country’s largest and most established aesthetic pharmaceutical producers. Supplied as a single 100-unit vial of lyophilised powder for reconstitution with sterile saline, Botulax is used for intramuscular injection to temporarily and reversibly relax targeted muscle activity, softening dynamic expression lines and reshaping facial contours. It is one of the most widely distributed Korean botulinum toxins worldwide and a core stock item for clinics and distributors looking for consistent quality at competitive wholesale pricing.

What Is Botulax 100U?

Botulax is a purified Clostridium botulinum toxin type A complex derived from the CBFC26 strain, produced by Hugel, Inc. in Chuncheon, South Korea. It has been used clinically in Korea for many years and is now exported to markets across Asia, the Middle East, Latin America and Europe. The same active substance developed by Hugel is marketed in the United States and Europe under the brand name Letybo (letibotulinumtoxinA), which received FDA approval for glabellar lines in 2024 — a useful signal of the manufacturing quality behind the Botulax name.

The product arrives as a sterile, vacuum-dried white powder in a single-use glass vial. Before treatment it is reconstituted with 0.9% sterile sodium chloride, allowing the practitioner to choose a dilution appropriate to the treatment area and the precision required. Botulax is also available in 200U and 300U presentations; the 100U vial is the most commonly stocked size because it suits typical single-session facial aesthetic use with minimal waste.

How Botulax Botulinum Toxin Works

Repeated contraction of facial muscles over years etches expression lines into the skin — frown lines between the brows, horizontal forehead lines, crow’s feet at the outer eye. Topical products cannot reach the cause of these lines because the cause is muscular, not dermal.

Botulax works at the neuromuscular junction. Once injected into the target muscle, the type A toxin blocks the release of acetylcholine, the neurotransmitter that signals a muscle to contract. Without that signal the muscle relaxes, the overlying skin stops being folded with every expression, and the line softens or disappears. Because the block is achieved through temporary and reversible chemical denervation, nerve terminals regenerate over the following months and normal muscle function returns in full — which is why treatment is repeated rather than permanent.

Onset is typically visible within 24 to 72 hours, with the full effect settling at around two weeks. As the treated muscles rest, the skin over them regains elasticity and resilience, and many patients report a smoother texture in the treated zone beyond the reduction of the line itself.

Key Benefits of Botulax 100U

Established Korean Manufacturing with Global Credibility

Hugel, Inc. is a publicly listed Korean pharmaceutical manufacturer (KOSDAQ: 145020) with large-scale toxin production capacity and export approvals across dozens of markets. For a distributor, that combination — proven supply volume plus international regulatory traction — makes Botulax a low-risk line to carry.

Predictable Onset and 3 to 6 Month Duration

Botulax delivers results within a few days and maintains them for approximately 3 to 6 months depending on the dose, the muscle treated and the individual patient’s metabolism. That duration supports a natural two-to-three treatments-per-year rebooking rhythm, which is the foundation of predictable recurring clinic revenue.

Strong Margin Against Western Toxin Brands

Korean botulinum toxins deliver comparable clinical performance to Western-branded products at a substantially lower acquisition cost. For high-volume clinics running regular toxin days, and for distributors serving price-sensitive markets, that cost difference is the single biggest driver of switching to Botulax.

Flexible Dilution for Precise Dosing

Because Botulax is supplied as a powder rather than a pre-mixed solution, the injector controls the concentration. A low dilution concentrates units into a small volume for tight, targeted work such as the glabella; a higher dilution spreads units across a broader field for areas like the forehead or for hyperhidrosis. See the reconstitution guide below.

Single-Vial Format with Minimal Waste

The 100-unit vial matches typical full-face aesthetic dosing for one patient, or splits comfortably across two patients on the same treatment day, keeping unused product to a minimum.

Botulax 100U Product Specifications

Aesthetic Applications of Botulax 100U

Upper Face — Frown Lines, Forehead and Crow’s Feet

The upper face is where botulinum toxin type A does its most recognisable work. Botulax softens vertical glabellar lines between the eyebrows by relaxing the corrugator and procerus muscles, smooths horizontal forehead lines across the frontalis, and reduces crow’s feet at the lateral orbicularis oculi. Precise placement at the lateral brow also produces a subtle chemical brow lift, opening the eye area without surgery.

Lower Face — Lips, Perioral Lines and Jawline

Lower-face work is more technique-sensitive but highly requested. Botulax is used to soften perioral lines and refine the shape of the lip border, to perform a lip flip that everts the upper lip without adding volume, to correct a gummy smile, and to relax a dimpled or “orange-peel” chin. Injection into the masseter muscle slims a wide or square jaw over several weeks, producing the tapered lower-face contour that drives much of the demand for Korean toxin brands.

Neck, Body and Hyperhidrosis

Beyond the face, Botulax is applied to horizontal neck lines (Venus rings) and to platysmal banding for a lifted neck contour, and to the gastrocnemius for calf slimming. It is also widely used for hyperhidrosis — excessive sweating of the underarms, palms and soles — where blocking cholinergic signalling to the sweat glands can reduce sweat production for several months at a time.

Therapeutic Uses of Botulinum Toxin Type A

Beyond aesthetics, botulinum toxin type A has an extensive record of therapeutic use. Applications reported for the molecule include:

• Blepharospasm and strabismus — involuntary eyelid spasm and eye muscle misalignment
• Cervical dystonia and torticollis — involuntary neck muscle contraction
• Focal spasticity — muscle tightness affecting the elbow, wrist, fingers, ankle or toes
• Chronic migraine prophylaxis — reducing the frequency and recurrence of headache episodes
• Neurogenic overactive bladder and urinary incontinence
• Primary hyperhidrosis — axillary, palmar and plantar
• Temporomandibular disorder (TMD) and bruxism-related masseter hypertrophy
• Phantom limb pain and selected chronic pain presentations

Botulax 100U Reconstitution and Dilution Guide

Botulax 100U is reconstituted with preservative-free 0.9% sterile sodium chloride. Draw the saline slowly and inject it down the inner wall of the vial; the vacuum will pull it in. Do not shake — swirl gently until fully dissolved, as vigorous agitation can denature the toxin. The reconstituted solution should be clear, colourless and free of particulate matter.

Once reconstituted, store the vial at 2°C to 8°C and use within 24 hours. Do not freeze reconstituted product. Use a fresh sterile needle for each patient and discard any remaining solution in line with your clinical waste protocol.

Botulax Administration Chart: Common Treatment Areas

Storage, Handling and Shelf Life

• Unopened vials: store refrigerated at 2°C to 8°C. Do not freeze.
• Protect from light — keep vials in the original carton, away from direct sunlight.
• After reconstitution: keep at 2°C to 8°C and use within 24 hours.
• Shelf life: 24 months unopened from date of manufacture.
• Cold chain: ship and receive with temperature-controlled packaging; inspect vials on arrival and reject any with compromised seals or evidence of freezing.
• Single use only — never reuse a vial, syringe or needle between patients.

Safety, Contraindications and Administration

Botulinum toxin type A is contraindicated in patients with known hypersensitivity to any component of the formulation, active infection at the proposed injection site, and neuromuscular disorders such as myasthenia gravis, Lambert-Eaton syndrome or amyotrophic lateral sclerosis. It is not recommended during pregnancy or breastfeeding. Caution is required in patients taking aminoglycoside antibiotics or other agents that interfere with neuromuscular transmission.

Common transient side effects include injection-site bruising, redness, swelling, headache and temporary heaviness of the brow. Rare adverse events include eyelid or brow ptosis and asymmetry, usually resulting from unintended toxin spread and typically resolving as the effect wears off. Practitioners should take a full medical history, document prior toxin treatments and obtain informed consent before every session.

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Frequently Asked Questions About Botulax 100U

What is Botulax 100U used for?

Botulax 100U is a botulinum toxin type A used to temporarily relax targeted muscles. In aesthetics it treats glabellar frown lines, forehead lines, crow’s feet, perioral lines, gummy smile, chin dimpling, masseter hypertrophy for jaw slimming and horizontal neck lines. It is also used therapeutically for conditions including hyperhidrosis, blepharospasm and cervical dystonia, subject to the indications licensed in each market.

Who manufactures Botulax?

Botulax is manufactured by Hugel, Inc., a publicly listed pharmaceutical company based in Chuncheon, South Korea. The same active substance is marketed in the United States and Europe under the brand name Letybo.

How many units are in a vial of Botulax 100U?

Each box contains one vial of 100 units of botulinum toxin type A as a lyophilised powder. Botulax is also available in 200-unit and 300-unit vials.

How long does Botulax last?

The effect of Botulax typically lasts 3 to 6 months, depending on the dose administered, the muscle treated, the treatment area and the individual patient’s metabolism. Larger muscles such as the masseter often hold results longer than fine facial muscles.

How long does Botulax take to work?

Initial effects usually appear within 24 to 72 hours of injection. The full result develops over approximately two weeks, which is when patients are normally reviewed for any top-up.

How do you reconstitute Botulax 100U?

Reconstitute with preservative-free 0.9% sterile sodium chloride. Adding 2.5 mL of saline to a 100U vial produces 4 units per 0.1 mL; adding 2.0 mL produces 5 units per 0.1 mL. Inject the saline gently down the inner wall of the vial and swirl rather than shake, as agitation can damage the toxin.

How should Botulax be stored?

Store unopened Botulax vials refrigerated at 2°C to 8°C, protected from light, and do not freeze. After reconstitution, keep the solution at 2°C to 8°C and use it within 24 hours. Unopened product has a 24-month shelf life.

Is Botulax the same as Botox?

No. Both are botulinum toxin type A products but they are separate brands from different manufacturers — Botulax is produced by Hugel in South Korea, while BOTOX® is a registered trademark of AbbVie/Allergan. They are not interchangeable, and unit potency is not directly transferable between botulinum toxin brands.

Does Botulax hurt?

Injections use a very fine needle and most patients describe only a brief sting. A topical anaesthetic cream applied 20 to 30 minutes beforehand makes the procedure more comfortable, particularly for sensitive areas such as the perioral region and the palms.

Can I buy Botulax 100U wholesale?

Yes. Fillers Wholesale supplies Botulax 100U at wholesale prices to clinics, distributors and licensed aesthetic practitioners, with volume discounts on bulk orders and cold-chain worldwide shipping. Contact our team for a quotation.

What is the difference between Botulax 100U and 200U?

The formulation is identical; only the quantity of toxin per vial differs. The 100U vial suits typical single-patient facial aesthetic sessions with minimal waste, while the 200U vial offers a lower cost per unit and is preferred by high-volume clinics and for larger-dose applications such as masseter, calf or hyperhidrosis treatment.

Is Botulax reversible?

The effect is temporary and self-reversing rather than reversible on demand. Botulax produces a temporary chemical denervation; nerve terminals regenerate over the following months and full muscle function returns without intervention. Unlike hyaluronic acid fillers, there is no dissolving agent that can reverse it immediately.

Related Products for Your Clinic

Stocking a full treatment room? Browse our complete range of wholesale botulinum toxins and dermal fillers — toxin and filler are routinely combined in the same appointment for a full-face result. Add a topical numbing cream to keep patients comfortable, and review our ODM / OEM services if you are developing your own branded line.